įor nodulocystic lesions of acne conglobata, a “cryoprobe” method has been applied with acceptable and long-term results. In 1967, Setrag Zacarian, who brought the term “cryosurgery” into use for the first time, designed a handheld cryosurgical device using liquid nitrogen which gave rise to several models of handheld cryosurgical units. In 1973, Goette also reported that liquid nitrogen cryotherapy was effective in treating acne. A study of 150 acne patients treated with liquid nitrogen cryotherapy reported excellent results in 95% of cases. Later reports in the 1970s mainly used liquid nitrogen as a cryogen source to treat acne. Allington used a cotton swab dipped in liquid nitrogen. Allington, who was the first to publish on the successful use of liquid nitrogen to treat acne. Liquid nitrogen (−196 ☌) became commercially available and was introduced into clinical practice in 1950 by Herman V. New York Daily Tribune, October 25, 1900, page 8, image 22. Ĭampbell White treating a skin lesion with sprayed liquid air as it appeared in the New York Tribune in 1900 (reproduced from the Library of Congress, Washington, DC. The degree of erythema and desquamation produced by cryotherapy is determined by the time the slush is in contact with the skin. to produce better results in papulopustular acne than in nodular lesions. In 1925 Giraudeau (cited by ) commenced using cryotherapy for acne, with a mixture of solid carbon dioxide (−78.5 ☌), acetone, and precipitated sulfur, which was later found out by Dobes et al. Arnott’s idea led to the development of a more practical cryotherapy device consisting of carbon dioxide collector and compressor units, which John Hall-Edwards described in 1911 ( Figure 2). James Arnott, Great Exhibition of London, 1851, for his development of cold therapy equipment (reproduced from the Metropolitan Museum of Art, New York City, used under a Creative Commons Attribution 1.0 Universal Public Domain Dedication).įrom Arnott’s early work, the practice of cryotherapy has blossomed into a staple in the practice of modern dermatology.
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